Combinatorial Chemistry — Synthesis of Opioid Peptide Receptor

Perspectives of peptide chemistry and combinatorial chemistry for proteomics

The main scientific objective of the project is to promote and facilitate proteomics studies by developing new technologies for the analysis of proteins in complex mixtures, that are complementary to conventional 2-dimensional gel electrophoresis. To reach this goal, the design, analytical development and industrial fabrication of a complete platform is pursued comprising a new generation of au...

Integrating natural product synthesis and combinatorial chemistry*,†

The fields of natural product total synthesis and combinatorial chemistry have major differences as well as much in common. Unique to combinatorial chemistry is the need to devise rapid and efficient methods for parallel synthesis and purification, while an area of overlap is the targeting of natural product scaffolds for combinatorial libraries. Both these aspects are illustrated with examples...

Combinatorial Chemistry and Multiple Parallel Synthesis

Synthesis of nocistatin C-terminal and it’s amide derivatives as an opioid peptide

A new biological active hexapeptide of C-terminal of nocistatin, contains Glu-Gln-Lys-Gln-Leu-Gln sequence was synthesized according to solid phase peptide synthesis on the surface of 2-chloro tritylchloride resin and using fmoc-protected amino acids in the presence of TBTU (O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyl uranium tetrafluoroborate) as a coupling reagent. Then, amidation of the C-te...

Combinatorial solid phase peptide synthesis and bioassays.

Solid phase peptide synthesis method, which was introduced by Merrifield in 1963, has spawned the concept of combinatorial chemistry. In this review, we summarize the present technologies of solid phase peptide synthesis (SPPS) that are related to combinatorial chemistry. The conventional methods of peptide library synthesis on polymer support are parallel synthesis, split and mix synthesis and...